Antiviral Efficacy & Zinc Ionophores

Before everyone gets off on a bender on how freaking ignorant the anti-vaxers who are overdosing on ivermectin right now are — because that’s going ’round again this September 2021 — this was already looked into in early 2020. What they’re trying to do is acquire a zinc ionophore to pair with zinc since they cannot access the human version offered by the FLCCC Alliance due to high demand — as I understand it, a preventive prescription can be gotten to have on hand, but the line is long. A zinc ionophore boosts the beneficial activity of zinc, which is antiviral.

Quercetin and epigallocatechin-gallate (of green tea) are other options. The Zelenko Protocol also includes vitamin C and D3. A protocol by Dr. Zelenko, a family practitioner in NY who had to modify his protocol due to ban of iver and hcq, now uses these alternatives. It’s not espoused to be perfect, but his intention was to keep patients out of the hospital. He was able to submit an initial weak study, due to the early pressures of the CV19 Situation.

Ability to treat CV19 symptoms early has already been shown to potentially affect hospital admission rates/discharge.

Studies Supporting Zinc with Zinc Ionophore

Derwand R, Scholz M, Zelenko V. COVID-19 outpatients: early risk-stratified treatment with zinc plus low-dose hydroxychloroquine and azithromycin: a retrospective case series study. International Journal of Antimicrobial Agents. 2020; 56: 106214. URL: (https://www.sciencedirect.com/science/article/pii/S0924857920304258).
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Dabbagh-Bazarbachi H, et al. Zinc ionophore activity of quercetin and epigallocatechin-gallate: from Hepa 1-6 cells to a liposome model. J Agric Food Chem. 2014; 62(32): 8085-93. URL: (https://pubmed.ncbi.nlm.nih.gov/25050823/). doi: 10.1021/jf5014633.
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World Scientific News. Antiviral Activities of Zn2+ Ions for Viral Prevention, Replication, Capsid Protein in Intracellular Proliferation of Viruses. WSN. 2018; 97: 28-50. URL: (http://www.worldscientificnews.com/wp-content/uploads/2018/02/WSN-97-2018-28-50-2.pdf?fbclid=IwAR2QnrX1mG9ONy-aQBiu4FqhR9nlNnRIVD44D74Y-6E7hJO_-QRhF83VYlY).
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te Velthuis A, van den Worm S, Sims AC, Baric RS. Zn Inhibits Coronavirus and Arterivirus RNA Polymerase Activity In Vitro and Zinc Ionophores Block the Replication of These Viruses in Cell Culture. PLoS Pathogens. 2010; 6(11): e1001176. URL: (https://www.researchgate.net/publication/47794995_Zn_Inhibits_Coronavirus_and_Arterivirus_RNA_Polymerase_Activity_In_Vitro_and_Zinc_Ionophores_Block_the_Replication_of_These_Viruses_in_Cell_Culture?fbclid=IwAR1yGDh1pshu48GZ8t026kOCVt74jYWTFG1y3-0iYC3Q0wgn2ixF5LEh1S8).
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Carlucci PM, et al. Zinc sulfate in combination with a zinc ionophore may improve outcomes in hospitalized COVID-19 patients. Journal of Medical Microbiology. 2020; 69: 1228–1234. URL: (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7660893/pdf/jmm-69-1228.pdf). DOI 10.1099/jmm.0.001250

Zelenko Protocol

I have individual ingredients for the Zelenko Protocol on hand for my family (looks like he developed his own formula this past year, also), due to the above references. More detailed information is included at the link, but the following are the guidelines it gives as I would use it:

Taken only as symptoms indicate, and ramping up if any symptoms are felt, as a preventive/when we catch it — because I’m not kidding myself, no matter how much precaution we use, and it looks like it’s going to stick around like flu has — up to these amounts is what I’ll aim for depending on symptom cues:

• Supportive care with fluids, fever control, and rest
• Elemental Zinc, 20-40 mg
• Vitamin D3, 5000 iu
• Vitamin C, 1000 mg
• Quercetin, 500 mg (1-2 times)
• If Quercetin unavailable then Epigallocatechin-gallate (EGCG) instead, 400 mg

For my kids, I’d use approximately/up to half these amounts for their size/age/weight. I don’t usually use the exact amount; I titrate up from half of what’s suggested for natural supplements, as needed, within known safe ranges. Titrating allows for caution. Not fearing to get a little aggressive, if necessary, is how I deal with symptoms in my household at the midpoint they need a little more help before they taper away.

And it appears to me that only something like ivermectin that people can be prescribed would make that any more efficacious. But in absence of ivermectin, for patients who qualify there’s monoclonal antibody therapy that can be pursued as soon as a positive test was shown since the earlier this therapy is used if infected, the more effective it is. (Cohen M. Monoclonal Antibodies to Disrupt Progression of Early Covid-19 Infection. New England Journal of Medicine Editorial, 21 January 2021.)

I also keep liposomal glutathione, as that was shown in a case study to help resolve a patient’s respiratory stress (2000 mg was the dose used… interestingly, they also had history of Lyme’s). I also have NAC for liver/respiratory support (and, since I have looked this up before, would use up to 500 mg 1-2 times per day focusing on an evening dose), though its sale has been removed from Amazon. The specific supplements used in my home are linked in a list on my post for Aubby’s Clean Brand Picks.

At the very least, I fear being hospitalized less than others fear it. But I fall into the group of people in the initial Zelenko study who had asthma and would be more prone to shortness of breath, though my asthma is basically “controlled” and I’ve mostly forgotten I have an inhaler.

We attended an initial meeting with Aubby’s new school to introduce her and to meet the staff. She ended up with vomiting and fever a couple days later, and the protocol kept her fever well controlled and reduced her vomiting also.

Suffice to say, as a parent of a special needs child with a medically fragile diagnosis, I like to have options and be prepared the best I can. This is the best OTC suggestion I’ve found, aside from the other ideas mentioned at the end of my other CV19 post. I’ll probably use this protocol in my household for “flu season” now forever (as needed) for my kids when they exhibit symptoms, and lysine for antiviral prophylaxis such as was done in the Dominican Republic, in addition to live probiotic since that also allowed Aubby to be the only Pre-K kid in her class of six or seven not to get sick all schoolyear in 2019-2020.

Regarding Dewormer Use

In December 2020, this doctor spoke in a Senate hearing on use of ivermectin (video in link is 10:39): Dr. Pierre Kory US Senate hearing – Ivermectin is 100% cure for COVID-19.

On topic of animal dewormer — a reply I made to a friend:

I appreciate your skepticism, and there’s a lot that’s crap like all groups have, but deep dives have shown me information suggesting otherwise. It’s literally what I was complaining about in a previous post on my profile regarding search results. I could find information on parasites implicated in chronic conditions on other search engines (such as a health manual I found through NIH references), but couldn’t find the same on the preferred search engines. I also found an implication in a UTI study from the 90’s (which is when most widely available modern-foundational study information stops). The dewormer groups aren’t complete bunk, they’re largely health conditions dismissed by their doctors and exploring that potential for themselves.

To be clear, I understand dewormers are primarily used for animals, particularly the ones mentioned in the groups you are reporting. However, occasionally people do get dewormed. It’s not unheard of. Similarly in weight of importance, SIBO is a Candida issue that I’ve been working with for years now and has been dismissed by GI. Yet I’ve gotten results, but why would I. Parasites and smaller critters are a part of a triangle: Candida overgrowth (Dr Orian Truss has written on it, and was the first doctor I saw write on it in the 80’s), heavy metals, and parasites/small organisms. Synthetics and heavy metals in food and environmental pollution bog down the body’s organs, which creates Candida overgrowth. Parasites/small organisms feed on metals, but they also often create anemic conditions and feed on things otherwise, but buildup of their biofilm also blocks nutrient absorption. Those issues often come together.

This is why I harp on diet and detox so much, using this corner of information in studies I find, and information related to gut health. I changed my child’s diet to non-GMO organic, water to ultra filtered and balanced electrolytes, did detox with good quality zeolite to unburden heavy metals, and helped her with live soil based probiotic to help Candida and replenish microbiome, and now fulvic minerals, magnesium, and calcium to replenish further which has also nearly eliminated my son’s eczema staph complications. It turned my child from a failing liver metabolic panel into one almost back in range when retested nine months later. No specialist she’s seen has had that answer. They were ready to blame me for nutritional malabsorption until I understood it by myself.

Anyway, an alternative perspective due to information having worked.

Selfsame friend still thinks me nuts to desire use of supplements over the as-yet-still experimental (though approved under the name Comirnaty… “Community”?, that’s the legal brand name, though the EUA supply is still being used interchangeably) vaccines available for the CV19 mess, but I’m resigned to that. I’ve weighed and measured my course as I have any other life/death choice I’ve had to make in the past six years, and I will, Gods willing, not be found wanting. But early treatment with preventives should be a good key, at minimum to have on hand.

To further press the point of ivermectin, check out FLCCC Alliance’s Review of the Emerging Evidence Demonstrating the Efficacy of Ivermectin in the Prophylaxis and Treatment of COVID-19, peer-reviewed and published by the American Journal of Therapeutics [May/June 2021; 28(3): e299-e318, doi: 10.1097/MJT.0000000000001377]. [PDF direct link]

There’s a thought I had, though. What if another future of medicine — rather than a pill for every ill and a vaccine/experimental gene therapy to bridge the gap between natural immune system function and synthetic “herd immunity” and synthetic “health” — was to be strategic use of ionophores? (Rhetorical question.)

Ivermectin vs The CV19 Vaccine Debate

Interesting watch/interview of a former FLCCC Alliance member and how the ivermectin debate has gotten grouped with what is perceived as anti-vaccine:

My thought is he makes good points, but seems to me his biggest reason for leaving was being labeled anti-vax in conjunction with tag explosion by unintended groups.

But he makes good points on there needing to be a balance in information, though I think that should include not ignoring both sides of vaccination once he gets going on how they should be the #1 defense. My opinion only changed after my parental experience in conjunction with Shoenfeld 2011 regarding autoimmune/inflammation by adjuvants. Basic health practices (diet, clean environment, etc.) should be #1, as they are the base from which medicine works/ operates/ adjusts, and they still are not currently.

Additionally, I think there’s a lot of overuse (antibiotics, steroids and immunosuppressants as opposed to root seeking, unnecessary vaccines like flu and chicken pox vs necessary like polio, etc.), and need for accountability (eliminate the 1986 National Childhood Vaccine Injury Act, and eliminate the PREP Act Immunity from Liability on the CV19 vaccines and acknowledge vaccine-injured individuals who are censored as the FLCCC/others have been censored or called “coincidence”).

More Ionophore Action Not Covered In This Post

Agrawal PK, Agrawal C, Blunden G. Quercetin: Antiviral Significance and Possible COVID-19 Integrative Considerations. 4 November 2020; 15(12): 1-10. URL: (https://journals.sagepub.com/doi/full/10.1177/1934578X20976293).

Quercetin is mentioned: Li X, et al. Network Bioinformatics Analysis Provides Insight into Drug Repurposing for COVID-2019. (pre-print) 2020; doi: 10.20944/preprints202003.0286.v1. 

Also on quercetin: Li X, et al. Quercetin, Inflammation and Immunity. Nutrients. 2016; 8(3): 167. doi: 10.3390/nu8030167.

Starting with this one for quercetin, some brief videos available describing studies by Found My Fitness.

Regarding use of tetra-O-galloyl-beta-D-glucose (TGG) and luteolin: Yi L, et al. Small molecules blocking the entry of severe acute respiratory syndrome coronavirus into host cells. J Virol. 2004; 78(20): 11334-9. doi: 10.1128/JVI.78.20.11334-11339.2004.

I also ran across forums threads mentioning animal ivermectin use as a skin cream… for rosacea. That made me curious, so I found… Forton FMN. The Pathogenic Role of Demodex Mites in Rosacea: A Potential Therapeutic Target Already in Erythematotelangiectatic Rosacea? Dermatol Ther (Heidelb). 2020; 10(6): 1229–1253.

People are often zinc deficient, so instead to note needing to watch for zinc toxicity: Fosmire GJ. Zinc toxicity. Am J Clin Nutr. 1990; 51(2): 225-227. doi: 10.1093/ajcn/51.2.225.